Progress in Application of Concentrated Growth Factor in Oral Tissue Regeneration / 中国医学科学院学报

Tissue regeneration is an important engineering method for the treatment of oral soft and hard tissue defects.Growth factors,as one of the three elements of tissue regeneration,are a necessary condition for tissue regeneration.Concentrated growth factor(CGF)is a new generation of blood extract prepared by changing the centrifugal speed on the basis of the preparation of platelet-rich plasma(PRP)and platelet-rich fibrin(PRF).It contains abundant growth factors and a fibrin matrix with a three-dimensional network structure,being capable of activating angiogenesis and promoting tissue regeneration and healing.CGF has been widely used in the repair and regeneration of oral soft and hard tissues.This paper introduces the preparation and composition of CGF and reviews the application of CGF in oral implantation and the regeneration of oral bone tissue,periodontal tissue,and dental pulp tissue.

Therapeutic effect of early use of nicorandil on patients with myocardial infarction undergoing PCI and its influence on cardiac function／ / 心血管康复医学杂志

To observe therapeutic effect of early use of nicorandil on patients with myocardial infarction (MI) undergoing percutaneous coronary intervention (PCI) and its influence on cardiac function .Methods : A total of 124 MI patients undergoing PCI in our hospital from 2016 to 2018 were randomly and equally divided into PCI group and nicorandil + PCI group (received nicorandil based on PCI group ) , both groups were treated for 28d. Therapeutic effect , incidence of adverse , LVEF , LVEDd and cardiac index (CI) before and three months after PCI were recorded and compared between two groups .Results : Compared with PCI group , there was significant rise in total effective rate (72.6% vs .90.3%) , and significant reductions in incidence rates of recurrent angina pectoris (25.8% vs.11.3%) and malignant arrhythmia (22.6% vs.8.1%) in nicorandil + PCI group , P＜0. 05 all.Compared with before PCI , there were significant rise in LVEF and CI , and significant reduction in LVEDd in two groups on three months after PCI ;compared with PCI group , there were significant rise in LVEF [ (40.52 ± 4.38)% vs.(46.81 ± 4.53)%] and CI [ (2.43 ± 0.35) L·min－1 ·m－2 vs.(2.66 ± 0.38) L·min－1 ·m－2 ] , and significant reduction in LVEDd [ (54. 32 ± 6.23) mm vs.(48. 24 ± 5.34) mm] in nicorandil + PCI group on three months after PCI , P＝0.001 all.There was no significant difference in incidence rate of adverse drug reactions dur‐ing treatment between two groups , P＝0.753. Conclusion : Early use of nicorandil can significantly improve thera‐peutic effect , contribute to recovery of cardiac function with good safety in MI patients undergoing PCI , which is worth extending .

Effect of exogenous calcium on seed germination and seedling physiological characteristics of Lycium ruthenium / 中国中药杂志

<p><b>OBJECTIVE</b>In order to get the method for improving the salt resistance of Lycium ruthenium seeds and seedlings under NaCl stress, the seed germination and physiological characteristics of L. ruthenium seedlings was studied.</p><p><b>METHOD</b>Several physiological indexes of L. ruthenium seeds under NaCl stress, such as the germination rate (Gr), germination vigor (Gv), germination index (Gi), vigor index (Vi), and relative salt damage rate were measured. Other indexes of the seedlings like relative water contents (RWC) , chlorophyll contents, soluble protein contents, electrolyte leakage, the contents of malondialdehyde (MDA), and peroxidase (POD) were also measured.</p><p><b>RESULT</b>NaCl at lower concentration could promote the seed germination but inhibit the seed germination at higher concentration. After the treatment by CaCl2 at the different concentrations, all germination indexes were increased. With the increase of salt concentration, the relative water contents and the contents of chlorophyll were decreased, the content of MDA and electrolyte leakage were increased. The change trend of POD activity showed the first increase and then decrease with the increase of salt concentration, which was similar to that of the soluble protein. After the treatment by CaCl2, relative water contents, chlorophyll and POD activities were decreased more slowly, and also electrolyte leakage and MDA contents increased slowly.</p><p><b>CONCLUSION</b>The CaCl2 could significantly alleviate the damages to the seeds and seedlings of L. ruthenium under NaCl stress, and promote the salt resistance to the seeds and seedlings of L. ruthenium.</p>

Effect of basic salt and mixed salt-alkali stress tolerance on seed germination and seedling physiological characteristics of Astraglus membranaceus var. mongholicus / 中草药

Objective: To compare the effects of Na2CO3 and NaCl + Na2CO3 at different concentration on the seed germination and seedling physiological characteristics of Astraglus membranaceus var. mongholicus, analyze the stress degrees of the both two on A. membranaceus var. mongholicus, and search for the effective ways for improving the resistance of seeds and seedlings under salt stress. Methods: Several physiological indexes of A. membranaceus var. mongholicus seeds under different salt treatments, such as the germination vigor (Gv), germination rate (Gr), relative germination rate, and relative salt damage rate were measured. And other indexes of the seedlings like chlorophyll contents, soluble protein contents, the contents of malondialdehyde (MDA), the activities of superoxide dismutase (SOD), and peroxidase (POD) were also measured. Results: Na2CO3 and NaCl + Na2CO3 at lower concentration could promote the seed germination but inhibit the seed germination at higher concentration. The inhibition was increased with the concentration increasing. The germination indexes of each treatment had the significant differences compared with the control (P < 0.05). With the salt concentration increasing, the contents of chlorophyll and the soluble protein decreased, which was negatively correlated with the concentration. The content of MDA was increased and positively correlated with the concentration. The change trend of SOD activity showed the first increase and then decreased with the salt concentration increasing, which was similar to that of POD. The activities of both SOD and POD reached the peak at 50 mmol/L. Conclusion: The stress of NaCl + Na2CO3 is higher than that of Na2CO3 on the seeds and seedlings of A. membranaceus var. mongholicus.

Effects of different salt-alkaline stress on seed germination and physiological characteristics of Hedysarum polybotrys / 中国中药杂志

<p><b>OBJECTIVE</b>In order to get the method for improving the salt resistance of Hedysarum polybotrys seeds and seedlings under different salt-alkaline stress, the seed germination and physiological characteristics of H. polybotrys seedlings were studied.</p><p><b>METHOD</b>Several physiological indexes of H. polybotrys seeds under different salt-alkaline stress, such as the germination vigor, germination rate, relative germination rate, relative salt damage rate were measured. And others indexes of the seedlings like chlorophyll contents, soluble protein contents, the permeability of plasmalemma, the activities of POD and SOD were also measured.</p><p><b>RESULT</b>Different salt-alkaline stress decreased the germination rate, vigor of germinate, germination index, while relative salt damage rate increased. With the increased salt-alkaline concentration, the adverse effects became more obvious. The strength of the salts: Na2CO3 > Na2SO4 > NaCl. With the increase of the salt-alkaline concentration, the chlorophyll contents and the soluble protein contents decreased, but the permeability of plasmalemma increased. The change trend of SOD and POD activity was similar, it is increased firstly, and then decreased as the stress intensity extended, the most significant increase of Na2SO4 and Na2CO3 in the concentration of salt-alkaline was 25 mmol x L(-1), but NaCl was 50 mmol x L(-1).</p><p><b>CONCLUSION</b>The seeds and seedlings inhibition of the salts was Na2CO3 > Na2SO4 > NaCl.</p>

Clinical application of inferior vena cava filters / 中国介入影像与治疗学

With the advent of inferior vena cava filters as the main means to obviate pulmonary embolism (PE), there has been a rise in the number of filters inserted globally. This article reviewed several currently available filter models, outlined the clinical indications and complications for filter insertion and presented the clinic application of filters.

The degradation performance of AZ31 bioabsorbable magnesium alloy stent implanted in the abdominal aorta of rabbits / 介入放射学杂志

Objective To make a preliminary evaluation of the degradation of AZ31 bioabsorbable magnesium alloy stent implanted in the abdominal aorta of experimental rabbits.Methods Twelve AZ31 biodegradable magnesium alloy stents were separately deployed in the infrarenal abdominal aortas of twelve New Zealand white rabbits.Every three experimental rabbits were sacrificed each time at one,two,three and four months after the procedure of stenting.The stenting segment of the aortas were harvested,radiographod and sent for pathologic examination to observe the degradable performance of the stent.Results All animals survived form the operation in the scheduled follow-up period.Radiographically and pathologically,the stents were fully expanded with perfect shape one month after the procedure,and part of the stent struts began to be degraded and fractured in two months,resulting in the loss of its supporting function.Three months after the implantation most stents were corroded.and in four months all the stents become completely destroyed.The estimating time for producing complete degradation of AZ31 magnesium alloy stents in rabbit's aorta was 104.5 days.Conclusion AZ31 bioabsorbable magnesium alloy stents implanted in rabbit abdominal aorta will lose their radial force in two months.How to prolong the functioning time of the implanted stents is the next research target.

A case-control study on the risk factors for road injury / 中华流行病学杂志

<p><b>OBJECTIVE</b>To investigate the risk factors of road injury.</p><p><b>METHODS</b>Case-control study was used. From November 2001 to August 2002, 406 drivers who had 438 drivers who had not experienced a motor vehicle crash in Huanggu district, Shenyang city were recruited by randomly selection on time of day, day of week and site in the same period at same district. Face to face interviews with drivers were conducted according to a highly structured questionnaire covering the circumstances of the current trip, usual behavior and background characteristics of the drivers and the condition of motor vehicles. Stanford sleepiness scale and Epworth sleepiness scale were used to quantify acute and chronic sleepiness respectively.</p><p><b>RESULTS</b>Increased risk was associated with drivers who identified themselves as having chronic doziness (OR = 1.98, 95% CI: 1.26 - 3.12). Increase in risk was associated with measures of acute tiredness, but without statistical significance (OR = 2.38, 95% CI: 0.89 - 6.31). Comparing to permanent daytime work pattern, rotating shifts or permanent night-work pattern increased the risk of crash (OR = 2.09, 95% CI: 1.48 - 2.94). The risk of motor vehicle crash among the drivers who drank alcohol in the previous 6 hours was 3.59 times (95% CI: 1.13 - 11.39) of those drivers who did not drink. Driving violations also contributed to the increased risk of crash (OR = 1.73, 95% CI: 1.22 - 2.46).</p><p><b>CONCLUSION</b>Factors as chronic doziness, rotating shifts or permanent night-work pattern, driving under alcohol impairment, violation of motor vehicle regulation all significantly increased the risk of road injury. Acute sleepiness might serve as a potential risk factor for road injury.</p>

Driver sleepiness and risk of car crashes in Shenyang, a Chinese northeastern city: population-based case-control study / 生物医学与环境科学（英文）

<p><b>OBJECTIVE</b>To estimate the association of driver sleepiness with the risk of car crashes.</p><p><b>METHODS</b>A population-based case-control study was conducted in Shenyang, a northeastern city in China, between November 2001 and July 2002. The case group comprised 406 car drivers involved in crashes, and 438 car drivers recruited at randomly selected sites, and on the day of week, and the time of day when they were driving on highways in the study region during the study period were used as control groups. Face-to-face interviews with drivers were conducted according to a well-structured questionnaire covering the circumstances of their current trip and their background information. Stanford sleepiness scale and Epworth sleepiness scale were used to quantify acute sleepiness and chronic sleepiness respectively.</p><p><b>RESULTS</b>There was a strong association between chronic sleepiness and the risk of car crash. Significantly increased risk of crash was associated with drivers who identified themselves as sleepy (Epworth sleepiness score > or = 10 vs < 10; adjusted odds ratio 2.07, 95% confidence interval 1.30 to 3.29), but no increased risk was associated with measures of acute sleepiness.</p><p><b>CONCLUSIONS</b>Chronic sleepiness in car drivers significantly increases the risk of car crash. Reductions in road traffic injuries may be achieved if fewer people drive when they are sleepy.</p>